Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 10/20 | 0.35 |
| ▸ | CFTR | P13569 | 6/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30118755 | 1.00 | PDE10A (0.37) | PDE10ATDP1IDH1CFTRGABRG2 | |
| SCHEMBL23975808 | 1.00 | PDE10A (0.37) | PDE10ATDP1IDH1CFTRGABRG2 | |
| SCHEMBL30118727 | 0.89 | POLB (0.41) | PDE10ATDP1CFTR | |
| SCHEMBL23975634 | 0.89 | POLB (0.41) | PDE10ATDP1CFTR | |
| SCHEMBL30225295 | 0.89 | POLB (0.41) | PDE10ATDP1CFTR | |
| SCHEMBL23976296 | 0.89 | POLB (0.41) | PDE10ATDP1CFTR | |
| SCHEMBL23976744 | 0.83 | PDE10A (0.39) | PDE10ATDP1CFTRGABRG2GABRB3 | |
| SCHEMBL23976743 | 0.83 | PDE10A (0.39) | PDE10ATDP1CFTRGABRG2GABRB3 | |
| SCHEMBL23976570 | 0.83 | PDE10A (0.40) | PDE10ATDP1CFTRGABRG2GABRB3 | |
| SCHEMBL23975774 | 0.83 | PDE10A (0.40) | PDE10ATDP1CFTRGABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |