Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.30 |
| ▸ | SLC2A3 | P11169 | 3/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | SPR | P35270 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26228707 | 0.93 | HDAC1 (0.38) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL23976139 | 0.92 | HDAC1 (0.37) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL23976638 | 0.91 | HDAC1 (0.36) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL25922698 | 0.90 | MEN1 (0.36) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL23975777 | 0.90 | SYK (0.38) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL30118766 | 0.90 | SYK (0.38) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL23976776 | 0.89 | POLB (0.37) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL30118866 | 0.89 | HDAC1 (0.35) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL23975593 | 0.89 | HDAC1 (0.37) | HDAC1HDAC8HDAC6PDE10AMEN1 | |
| SCHEMBL23976897 | 0.89 | HDAC1 (0.37) | HDAC1HDAC8HDAC6PDE10AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |