Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.34 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30118646 | 1.00 | SYK (0.35) | SYKSLC2A1SLC2A3PDE10ALNPEP | |
| SCHEMBL23976645 | 1.00 | SYK (0.35) | SYKSLC2A1SLC2A3PDE10ALNPEP | |
| SCHEMBL30118726 | 1.00 | SYK (0.35) | SYKSLC2A1SLC2A3PDE10ALNPEP | |
| SCHEMBL23976471 | 1.00 | SYK (0.35) | SYKSLC2A1SLC2A3PDE10ALNPEP | |
| SCHEMBL23976815 | 0.97 | SYK (0.34) | SYKSLC2A1SLC2A3PDE10AGAA | |
| SCHEMBL23976129 | 0.97 | SYK (0.34) | SYKSLC2A1SLC2A3PDE10AGAA | |
| SCHEMBL23976813 | 0.97 | SYK (0.34) | SYKSLC2A1SLC2A3PDE10AGAA | |
| SCHEMBL25941902 | 0.96 | SYK (0.34) | SYKSLC2A1SLC2A3PDE10AGAA | |
| SCHEMBL23976727 | 0.95 | SYK (0.34) | SYKSLC2A1SLC2A3PDE10AGAA | |
| SCHEMBL23976780 | 0.92 | SLC2A1 (0.35) | SYKSLC2A1SLC2A3PDE10AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |