Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 5/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30118806 | 1.00 | PDE10A (0.39) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL23976258 | 1.00 | PDE10A (0.39) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL23986918 | 1.00 | PDE10A (0.39) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL30118779 | 1.00 | PDE10A (0.39) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL23975847 | 0.92 | PDE10A (0.38) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL23976250 | 0.92 | PDE10A (0.38) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL23975846 | 0.92 | PDE10A (0.38) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL23976257 | 0.90 | PDE10A (0.41) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL23975844 | 0.90 | PDE10A (0.41) | PDE10ATDP1KMT2AMEN1POLB | |
| SCHEMBL23976816 | 0.90 | PDE10A (0.41) | PDE10ATDP1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |