Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 8/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.44 |
| ▸ | LCK | P06239 | 7/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | TEC | P42680 | 1/20 | 0.42 |
| ▸ | TXK | P42681 | 1/20 | 0.42 |
| ▸ | BMX | P51813 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2397627 | 1.00 | ITK (0.47) | ITKABL1AURKBLCKEGFR | |
| SCHEMBL2393652 | 0.93 | ITK (0.47) | ITKABL1AURKBLCKEGFR | |
| SCHEMBL2393645 | 0.93 | ITK (0.47) | ITKABL1AURKBLCKEGFR | |
| SCHEMBL2396030 | 0.88 | ITK (0.49) | ITKABL1AURKBLCKEGFR | |
| SCHEMBL2396032 | 0.88 | ITK (0.49) | ITKABL1AURKBLCKEGFR | |
| SCHEMBL2370660 | 0.86 | ITK (0.51) | ITKAURKBLCKEGFRINSR | |
| SCHEMBL2370649 | 0.86 | ITK (0.51) | ITKAURKBLCKEGFRINSR | |
| SCHEMBL2396683 | 0.85 | ITK (0.57) | ITKABL1AURKBLCKEGFR | |
| SCHEMBL2396679 | 0.85 | ITK (0.57) | ITKABL1AURKBLCKEGFR | |
| SCHEMBL2398258 | 0.84 | ABL1 (0.46) | ITKABL1AURKBLCKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |