Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975757 | 1.00 | NPSR1 (0.39) | NPSR1USP2MEN1KMT2ATSHR | |
| SCHEMBL23975781 | 0.88 | NPSR1 (0.38) | NPSR1USP2MEN1KMT2ATSHR | |
| SCHEMBL23975784 | 0.88 | NPSR1 (0.38) | NPSR1USP2MEN1KMT2ATSHR | |
| SCHEMBL30225054 | 0.82 | NPSR1 (0.38) | NPSR1USP2MEN1KMT2ATSHR | |
| SCHEMBL23975749 | 0.82 | POLB (0.39) | NPSR1USP2MEN1KMT2ATSHR | |
| SCHEMBL23976302 | 0.81 | NPSR1 (0.39) | NPSR1USP2MEN1KMT2ATSHR | |
| SCHEMBL23975800 | 0.81 | POLB (0.39) | NPSR1MEN1KMT2ATSHRPOLB | |
| SCHEMBL23975635 | 0.81 | POLB (0.39) | NPSR1MEN1KMT2ATSHRPOLB | |
| SCHEMBL30225323 | 0.81 | POLB (0.39) | NPSR1MEN1KMT2ATSHRPOLB | |
| SCHEMBL23975708 | 0.78 | NPSR1 (0.31) | NPSR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |