Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25763777 | 0.84 | CA1 (0.40) | CA1CA2 | |
| SCHEMBL18124774 | 0.80 | CA1 (0.41) | CA1CA2SMN1; SMN2CA14ZDHHC7 | |
| Hydrochloric Acid SCHEMBL20303949 | 0.80 | CA1 (0.37) | CA1CA2SMN1; SMN2GRM4ZDHHC7 | |
| SCHEMBL14459291 | 0.79 | SMN1; SMN2 (0.37) | CA1CA2SMN1; SMN2CA14TSHR | |
| SCHEMBL26385278 | 0.79 | SMN1; SMN2 (0.37) | CA1CA2SMN1; SMN2CA14TSHR | |
| SCHEMBL20126571 | 0.78 | CA1 (0.36) | CA1CA2SMN1; SMN2CA14LMNA | |
| SCHEMBL21704813 | 0.78 | CA1 (0.33) | CA1CA2SMN1; SMN2GABRR1 | |
| SCHEMBL7105090 | 0.78 | SMN1; SMN2 (0.46) | CA1CA2SMN1; SMN2CA14TSHR | |
| SCHEMBL17308180 | 0.78 | SMN1; SMN2 (0.38) | CA1CA2SMN1; SMN2CA14ZDHHC7 | |
| SCHEMBL18232696 | 0.78 | CA1 (0.42) | CA1CA2SMN1; SMN2CA14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |