Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.33 |
| ▸ | SLC2A3 | P11169 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30118579 | 1.00 | MEN1 (0.34) | MEN1POLBKMT2AMAPTHDAC1 | |
| SCHEMBL23976126 | 1.00 | MEN1 (0.34) | MEN1POLBKMT2AMAPTHDAC1 | |
| SCHEMBL30118733 | 0.94 | MEN1 (0.34) | MEN1POLBKMT2AHDAC1HDAC8 | |
| SCHEMBL23976031 | 0.94 | MEN1 (0.34) | MEN1POLBKMT2AHDAC1HDAC8 | |
| SCHEMBL30118749 | 0.94 | MEN1 (0.34) | MEN1POLBKMT2AHDAC1HDAC8 | |
| SCHEMBL23976030 | 0.94 | MEN1 (0.34) | MEN1POLBKMT2AHDAC1HDAC8 | |
| SCHEMBL23976034 | 0.94 | MEN1 (0.34) | MEN1POLBKMT2AHDAC1HDAC8 | |
| SCHEMBL30225149 | 0.94 | MEN1 (0.34) | MEN1POLBKMT2AHDAC1HDAC8 | |
| SCHEMBL24702392 | 0.93 | MEN1 (0.34) | MEN1POLBKMT2AHDAC1HDAC8 | |
| SCHEMBL23976174 | 0.93 | MEN1 (0.34) | MEN1POLBKMT2AHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |