Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26106503 | 1.00 | EPHX2 (0.45) | EPHX2DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL23978950 | 1.00 | EPHX2 (0.45) | EPHX2DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL30337050 | 1.00 | EPHX2 (0.45) | EPHX2DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL23978559 | 1.00 | EPHX2 (0.45) | EPHX2DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL26105654 | 0.94 | TRPV1 (0.46) | EPHX2DHODHTRPV1ITGB2ICAM1 | |
| SCHEMBL30336947 | 0.94 | TRPV1 (0.46) | EPHX2DHODHTRPV1ITGB2ICAM1 | |
| SCHEMBL23978958 | 0.94 | TRPV1 (0.46) | EPHX2DHODHTRPV1ITGB2ICAM1 | |
| SCHEMBL23978574 | 0.94 | TRPV1 (0.46) | EPHX2DHODHTRPV1ITGB2ICAM1 | |
| SCHEMBL23979016 | 0.93 | EPHX2 (0.44) | EPHX2DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL30279384 | 0.93 | EPHX2 (0.44) | EPHX2DHODHTAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |