Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 14/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 14/20 | 0.44 |
| ▸ | ITGAL | P20701 | 14/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978724 | 0.97 | ITGB2 (0.41) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL23978797 | 0.94 | ITGB2 (0.40) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL24804736 | 0.86 | ITGB2 (0.40) | ITGB2ICAM1ITGAL | |
| SCHEMBL30083823 | 0.86 | ITGB2 (0.40) | ITGB2ICAM1ITGAL | |
| SCHEMBL24804737 | 0.86 | ITGB2 (0.40) | ITGB2ICAM1ITGAL | |
| SCHEMBL23978803 | 0.85 | ITGB2 (0.38) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL24804257 | 0.85 | ITGB2 (0.38) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL23978809 | 0.83 | ITGB2 (0.37) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL23978733 | 0.83 | ITGB2 (0.37) | ITGB2ICAM1ITGALSMN1; SMN2LMNA | |
| SCHEMBL24804676 | 0.83 | ITGB2 (0.37) | ITGB2ICAM1ITGALSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222789-A1 | INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-04 | — | — | WO | disclosed |