Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.49 |
| ▸ | IKZF2 | Q9UKS7 | 9/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23980636 | 0.93 | CRBN (0.58) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL25627461 | 0.88 | CRBN (0.48) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL23980469 | 0.88 | CRBN (0.58) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL25627454 | 0.83 | CRBN (0.48) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL25627576 | 0.83 | CRBN (0.48) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL25628797 | 0.79 | CRBN (0.61) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL23980559 | 0.79 | CRBN (0.57) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL23980477 | 0.77 | IKZF2 (0.74) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL23980479 | 0.77 | CRBN (0.64) | CRBNDDB1IKZF2CSNK1A1GSPT1 | |
| SCHEMBL23980576 | 0.75 | CRBN (0.61) | CRBNDDB1IKZF2CSNK1A1GSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222542-A1 | 5-AMINO-2-PIPERIDINON-3-YL-1-OXOISOINDOLINE DERIVATIVES FOR DEGRADATION OF IKZF2 DEGRADERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-11-04 | — | — | WO | disclosed |