SCHEMBL23980794

SCHEMBL23980794

O=C(O)c1ccc2nc(Cc3ccc(-c4cccc5c4OCC(c4ccc(Cl)cc4F)O5)cc3)n(C[C@@H]3CCO3)c2n1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GLP1R P43220 19/20 0.48
KCNH2 Q12809 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23980809 1.00 GLP1R (0.48) GLP1RKCNH2
SCHEMBL30217458 1.00 GLP1R (0.48) GLP1RKCNH2
SCHEMBL23980810 0.88 GLP1R (0.43) GLP1R
SCHEMBL23980892 0.84 GLP1R (0.62) GLP1RKCNH2
SCHEMBL30275379 0.84 GLP1R (0.62) GLP1RKCNH2
SCHEMBL30275383 0.84 GLP1R (0.62) GLP1RKCNH2
SCHEMBL23980759 0.84 GLP1R (0.62) GLP1RKCNH2
SCHEMBL23980904 0.84 GLP1R (0.62) GLP1RKCNH2
SCHEMBL23980797 0.84 GLP1R (0.62) GLP1RKCNH2
SCHEMBL30275368 0.84 GLP1R (0.62) GLP1RKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230295154-A1 HETEROCYCLIC GLP-1 AGONISTS SHOUTI INC. 2023-09-21 US disclosed
WO-2021219019-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. (US) 2021-11-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230295154-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, GCGR GLP1R 1/4885KCNH2 1462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.