Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 8/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 7/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | TEC | P42680 | 1/20 | 0.42 |
| ▸ | TXK | P42681 | 1/20 | 0.42 |
| ▸ | BMX | P51813 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2398342 | 1.00 | ITK (0.48) | ITKPIK3CDLCKAURKBPIK3CG | |
| SCHEMBL2399394 | 0.88 | PIK3CG (0.52) | ITKPIK3CDLCKAURKBPIK3CG | |
| SCHEMBL2399382 | 0.88 | PIK3CG (0.52) | ITKPIK3CDLCKAURKBPIK3CG | |
| SCHEMBL2400258 | 0.86 | ITK (0.47) | ITKPIK3CDLCKAURKBPIK3CG | |
| SCHEMBL2400272 | 0.86 | ITK (0.47) | ITKPIK3CDLCKAURKBPIK3CG | |
| SCHEMBL2369722 | 0.85 | PIK3CA (0.52) | ITKPIK3CDLCKAURKBPIK3CG | |
| SCHEMBL2369714 | 0.85 | PIK3CA (0.52) | ITKPIK3CDLCKAURKBPIK3CG | |
| SCHEMBL12293056 | 0.85 | PIK3CD (0.53) | PIK3CDLCKPIK3CGPIK3CA | |
| SCHEMBL2401269 | 0.85 | PIK3CD (0.60) | ITKPIK3CDLCKAURKBPIK3CG | |
| SCHEMBL2401283 | 0.85 | PIK3CD (0.60) | ITKPIK3CDLCKAURKBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |