Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30305520 | 1.00 | KDR (0.35) | KDRTGFBR1CSF1RAURKACSNK1D | |
| SCHEMBL30305562 | 0.88 | KDR (0.36) | KDRTGFBR1CSF1RAURKASLC6A2 | |
| SCHEMBL30305516 | 0.88 | KDR (0.36) | KDRTGFBR1CSF1RAURKASLC6A2 | |
| SCHEMBL30305451 | 0.88 | KDR (0.36) | KDRTGFBR1CSF1RAURKASLC6A2 | |
| SCHEMBL23984567 | 0.88 | KDR (0.36) | KDRTGFBR1CSF1RAURKASLC6A2 | |
| SCHEMBL30305561 | 0.88 | KDR (0.36) | KDRTGFBR1CSF1RAURKASLC6A2 | |
| SCHEMBL23985000 | 0.88 | KDR (0.36) | KDRTGFBR1CSF1RAURKASLC6A2 | |
| SCHEMBL23984566 | 0.88 | KDR (0.36) | KDRTGFBR1CSF1RAURKASLC6A2 | |
| SCHEMBL23985793 | 0.86 | KDR (0.35) | KDRTGFBR1CSF1RAURKASLC6A2 | |
| SCHEMBL23985210 | 0.86 | KDR (0.35) | KDRTGFBR1CSF1RAURKASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230353959-A1 | PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2023-11-02 | — | — | US | disclosed |
| WO-2021222556-A1 | PI3K-α INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |