SCHEMBL23985251

SCHEMBL23985251

COC1NC(=O)c2cccc(N)c21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.36
KDM4E B2RXH2 4/20 0.35
ALDH1A1 P00352 4/20 0.35
MAPT P10636 3/20 0.35
HPGD P15428 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
TNKS2 Q9H2K2 2/20 0.35
WEE1 P30291 1/20 0.34
TDP1 Q9NUW8 3/20 0.33
RAB9A P51151 2/20 0.33
CYP1A2 P05177 2/20 0.33
POLB P06746 2/20 0.33
CYP3A4 P08684 2/20 0.33
CYP2C9 P11712 2/20 0.33
MTOR P42345 2/20 0.33
BLM P54132 2/20 0.33
HSD17B10 Q99714 2/20 0.33
ROCK2 O75116 1/20 0.33
PRKCA P17252 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29872293 0.80 PBRM1 (0.46) KDM4EALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL26801767 0.77 TSHR (0.40) PARP1ALDH1A1MAPTTNKS2TDP1
SCHEMBL23985252 0.74 PARP1 (0.39) PARP1ALDH1A1MAPTTNKS2WEE1
SCHEMBL17797168 0.73 HSD17B10 (0.49) PARP1KDM4EALDH1A1MAPTHPGD
SCHEMBL29583995 0.73 HSD17B10 (0.49) PARP1KDM4EALDH1A1MAPTHPGD
Hydrochloric Acid SCHEMBL30566045 0.72 HTR2A (0.47) PARP1KDM4EALDH1A1MAPTHPGD
SCHEMBL23985895 0.67 PARP1 (0.38) PARP1KDM4EALDH1A1MAPTHPGD
SCHEMBL4914480 0.67 PARP1 (0.46) PARP1
SCHEMBL30566051 0.64 HSD17B10 (0.44) PARP1KDM4EALDH1A1MAPTHPGD
Water SCHEMBL503139 0.64 PARP1 (0.37) PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230353959-A1 PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. 2023-11-02 US disclosed
US-20230353959-A1 PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. 2023-11-02 US disclosed
EP-4143196-A1 PI3K-a INHIBITORS AND METHODS OF USE THEREOF Relay Therapeutics, Inc. (US) 2023-03-08 EP disclosed
WO-2021222556-A1 PI3K-α INHIBITORS AND METHODS OF USE THEREOF RELAY THERAPEUTICS, INC. (US) 2021-11-04 WO disclosed