Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 8/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 8/20 | 0.47 |
| ▸ | ATR | Q13535 | 3/20 | 0.47 |
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12266641 | 0.85 | ATM (0.52) | ATMPIK3CAATRCLK4CLK1 | |
| SCHEMBL27645746 | 0.81 | PIK3CA (0.53) | ATMPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL930563 | 0.79 | PIK3CA (0.76) | ATMPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL30275040 | 0.79 | PIK3CA (0.55) | ATMPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL29758332 | 0.79 | PIK3CA (0.55) | ATMPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1558995 | 0.78 | IP6K1 (0.41) | ATMPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL367320 | 0.78 | PIK3CA (0.47) | ATMPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14914599 | 0.78 | PIK3CA (0.47) | ATMPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL928053 | 0.77 | PIK3CA (0.61) | ATMPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1559281 | 0.77 | MTOR (0.43) | ATMPIK3CAPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
| WO-2009155527-A9 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PIK3CA, AKT1, PIK3R5 | ATM 604/4885PIK3CA 1/4885PIK3CD 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.