Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 16/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395275 | 0.83 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL2395488 | 0.82 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL2398905 | 0.80 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL2397564 | 0.75 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL2396722 | 0.73 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL6273930 | 0.72 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL1787285 | 0.72 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL2396790 | 0.72 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL48634 | 0.72 | PIK3CG (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3C2A | |
| SCHEMBL2398780 | 0.70 | PIK3CA (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017608-B2 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2011-09-13 | — | — | US | disclosed |
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |