Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396380 | 0.99 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2397564 | 0.86 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2396790 | 0.80 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2395479 | 0.80 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2396615 | 0.80 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2398723 | 0.80 | PIK3CD (0.41) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2398248 | 0.79 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL48660 | 0.76 | PIK3CG (1.00) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB | |
| SCHEMBL2397832 | 0.76 | MEN1 (0.61) | PIK3CDPIK3CAPIK3CGPIK3CBMEN1 | |
| SCHEMBL2399363 | 0.76 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CGPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017608-B2 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2011-09-13 | — | — | US | disclosed |
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| US-20060148822-A1 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2006-07-06 | — | — | US | disclosed |
| EP-1608647-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | Novartis AG (CH) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004078754-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148822-A1 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | MAP3K13, AKT3, MAP3K3 | PIK3CD 42/4885PIK3CA 4/4885PIK3CG 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.