Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.68 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.65 |
| ▸ | FLT1 | P17948 | 3/20 | 0.55 |
| ▸ | FLT4 | P35916 | 3/20 | 0.55 |
| ▸ | BMP4 | P12644 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.46 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988761 | 0.89 | KDR (0.67) | KDRACVR1FLT1FLT4BMP4 | |
| SCHEMBL7618559 | 0.82 | KDR (0.77) | KDRACVR1FLT1FLT4BMP4 | |
| SCHEMBL7618989 | 0.81 | KDR (1.00) | KDRACVR1FLT1FLT4BMP4 | |
| SCHEMBL17442156 | 0.79 | ACVR1 (1.00) | KDRACVR1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL24409675 | 0.79 | ACVR1 (1.00) | KDRACVR1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL23988902 | 0.79 | KDR (0.54) | KDRACVR1FLT1FLT4BMPR1B | |
| SCHEMBL23988764 | 0.77 | ACVR1 (0.69) | KDRACVR1FLT1FLT4BMPR1B | |
| SCHEMBL23988994 | 0.76 | KDR (0.67) | KDRACVR1FLT1FLT4BMP4 | |
| SCHEMBL7613010 | 0.75 | KDR (0.76) | KDRFLT1FLT4BMP4 | |
| SCHEMBL23988891 | 0.75 | KDR (0.65) | KDRACVR1FLT1FLT4BMP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |