Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 18/20 | 0.70 |
| ▸ | BMPR1A | P36894 | 8/20 | 0.69 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.62 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.62 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.62 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.62 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.62 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.62 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | BMP4 | P12644 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23988759 | 0.94 | ACVR1 (0.79) | ACVR1BMPR1ABMPR1BACVRL1ACVR2A | |
| SCHEMBL19110528 | 0.82 | ACVR1 (0.87) | ACVR1BMPR1ABMPR1BACVRL1ACVR2A | |
| SCHEMBL17442183 | 0.82 | ACVR1 (1.00) | ACVR1BMPR1ABMPR1BACVRL1ACVR2A | |
| SCHEMBL17442419 | 0.82 | ACVR1 (1.00) | ACVR1BMPR1ABMPR1BACVRL1ACVR1B | |
| SCHEMBL24409780 | 0.82 | ACVR1 (1.00) | ACVR1BMPR1ABMPR1BACVRL1ACVR1B | |
| SCHEMBL23988798 | 0.82 | KDR (0.60) | ACVR1BMPR1ABMPR1BACVRL1ACVR1B | |
| SCHEMBL17442465 | 0.81 | ACVR1 (1.00) | ACVR1BMPR1ABMPR1BACVRL1ACVR2A | |
| SCHEMBL23988758 | 0.80 | ACVR1 (0.57) | ACVR1BMPR1ABMPR1BACVRL1ACVR1B | |
| SCHEMBL23988764 | 0.80 | ACVR1 (0.69) | ACVR1BMPR1ABMPR1BACVRL1ACVR2A | |
| SCHEMBL19110533 | 0.80 | ACVR1 (0.78) | ACVR1BMPR1ABMPR1BACVRL1ACVR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222875-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |