SCHEMBL23988970

SCHEMBL23988970

CCc1cc(F)cc(C(=O)OC)c1N

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.49
POLB P06746 1/20 0.49
GAA P10253 5/20 0.41
ALDH1A1 P00352 5/20 0.41
HSD17B10 Q99714 3/20 0.41
MAPT P10636 3/20 0.41
HPGD P15428 3/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.41
GLA P06280 1/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40
ATM Q13315 1/20 0.40
CFTR P13569 3/20 0.40
ABL1 P00519 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10175289 0.83 KDM4E (0.40) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL10174556 0.81 KDR (0.39) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL19840664 0.81 KDM4E (0.49) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL505595 0.81 KDM4E (0.49) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL19526275 0.80 CFTR (0.54) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL1004680 0.79 GAA (0.50) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL1060105 0.79 KDM4E (0.47) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL25087418 0.79 KDM4E (0.44) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL19526295 0.78 CFTR (0.42) KDM4EPOLBGAAALDH1A1HSD17B10
SCHEMBL8188265 0.78 KDM4E (0.46) KDM4EPOLBGAAALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3901138-A1 COMPOUND FOR USE IN RETINAL DISEASES Medshine Discovery Inc. (CN) 2021-10-27 EP disclosed