Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | MDM4 | O15151 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30224478 | 1.00 | JAK2 (0.39) | JAK2JAK3PTK2SLC6A2SLC6A4 | |
| SCHEMBL23992936 | 1.00 | JAK2 (0.39) | JAK2JAK3PTK2SLC6A2SLC6A4 | |
| SCHEMBL23992939 | 0.93 | JAK2 (0.33) | JAK2JAK3PTK2QPCTQPCTL | |
| SCHEMBL30224736 | 0.93 | JAK2 (0.33) | JAK2JAK3PTK2QPCTQPCTL | |
| SCHEMBL23992940 | 0.93 | JAK2 (0.33) | JAK2JAK3PTK2QPCTQPCTL | |
| SCHEMBL30224613 | 0.91 | SLC6A4 (0.36) | JAK2JAK3PTK2SLC6A4QPCT | |
| SCHEMBL23992933 | 0.91 | SLC6A4 (0.36) | JAK2JAK3PTK2SLC6A4QPCT | |
| SCHEMBL23992932 | 0.91 | SLC6A4 (0.36) | JAK2JAK3PTK2SLC6A4QPCT | |
| SCHEMBL23993918 | 0.88 | SYK (0.38) | QPCTQPCTLSYKMDM2PPARD | |
| SCHEMBL23993674 | 0.86 | QPCT (0.33) | QPCTQPCTLMDM2PPARDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |