Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 13/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.59 |
| ▸ | LCK | P06239 | 10/20 | 0.59 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.38 |
| ▸ | MERTK | Q12866 | 2/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2399332 | 1.00 | ITK (0.59) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL2370863 | 0.99 | ITK (0.60) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL2370895 | 0.99 | ITK (0.60) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL2398982 | 0.91 | ITK (0.57) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL2398991 | 0.91 | ITK (0.57) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL2398519 | 0.90 | ITK (0.55) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL2398530 | 0.90 | ITK (0.55) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL12290901 | 0.87 | ITK (0.57) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL2395616 | 0.86 | ITK (0.56) | ITKAURKBLCKSSTR5RORC | |
| SCHEMBL136865 | 0.86 | ITK (0.72) | ITKAURKBLCKSSTR5RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |