Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30224836 | 1.00 | PPARD (0.36) | PPARDSCN9AMDM2CYP1A2METAP2 | |
| SCHEMBL23993464 | 1.00 | PPARD (0.36) | PPARDSCN9AMDM2CYP1A2METAP2 | |
| SCHEMBL30224657 | 0.92 | PDE10A (0.36) | PPARDSCN9APDE10A | |
| SCHEMBL23993822 | 0.92 | PDE10A (0.36) | PPARDSCN9APDE10A | |
| SCHEMBL23993110 | 0.91 | ABL1 (0.34) | PPARDMDM2CYP1A2METAP2RAF1 | |
| SCHEMBL30224302 | 0.91 | ABL1 (0.34) | PPARDMDM2CYP1A2METAP2RAF1 | |
| SCHEMBL23994335 | 0.91 | CYP1A2 (0.38) | PPARDMDM2CYP1A2METAP2RAF1 | |
| SCHEMBL23993469 | 0.91 | CYP1A2 (0.38) | PPARDMDM2CYP1A2METAP2RAF1 | |
| SCHEMBL23993474 | 0.88 | PPARD (0.34) | PPARDMDM2PDE10AMTORABL1 | |
| SCHEMBL23993471 | 0.88 | PPARD (0.34) | PPARDMDM2PDE10AMTORABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |