Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994708 | 1.00 | PPARD (0.38) | PPARDALDH1A1CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL23994018 | 0.92 | PPARD (0.37) | PPARDACP1F2RL3PDE4DQPCT | |
| SCHEMBL30224235 | 0.92 | PPARD (0.37) | PPARDACP1F2RL3PDE4DQPCT | |
| SCHEMBL23994831 | 0.91 | PPARD (0.37) | PPARDALDH1A1CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL30181987 | 0.91 | PPARD (0.37) | PPARDALDH1A1CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL30181563 | 0.89 | AKT1 (0.36) | PPARDACP1QPCTQPCTLNPC1 | |
| SCHEMBL23993478 | 0.89 | AKT1 (0.36) | PPARDACP1QPCTQPCTLNPC1 | |
| SCHEMBL23994710 | 0.87 | MTOR (0.38) | PPARDALDH1A1CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL23992885 | 0.86 | MTOR (0.38) | PPARDALDH1A1CYP1A2HSD17B10CYP3A4 | |
| SCHEMBL30224155 | 0.86 | MTOR (0.38) | PPARDALDH1A1CYP1A2HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |
| CN-115698009-A | CD73 inhibiting 2,4-dioxopyrimidine compounds | 吉利德科学公司 | 2023-02-03 | — | — | CN | disclosed |