Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 14/20 | 0.36 |
| ▸ | TP53 | P04637 | 6/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
| ▸ | BRD2 | P25440 | 4/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30224472 | 1.00 | MDM2 (0.36) | MDM2TP53MTORBRD4BRD2 | |
| SCHEMBL23994733 | 1.00 | MDM2 (0.36) | MDM2TP53MTORBRD4BRD2 | |
| SCHEMBL23993918 | 0.89 | SYK (0.38) | MDM2TP53MTORSYK | |
| SCHEMBL23994033 | 0.89 | MTOR (0.35) | MDM2TP53MTORSYK | |
| SCHEMBL23994060 | 0.88 | JAK2 (0.35) | MDM2TP53MTORSYK | |
| SCHEMBL23994022 | 0.88 | MDM2 (0.40) | MDM2TP53 | |
| SCHEMBL25005485 | 0.88 | MDM2 (0.41) | MDM2TP53 | |
| SCHEMBL25005483 | 0.88 | MDM2 (0.41) | MDM2TP53 | |
| SCHEMBL23994023 | 0.88 | MDM2 (0.41) | MDM2TP53 | |
| SCHEMBL23995073 | 0.88 | MDM2 (0.40) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |