Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994838 | 1.00 | SYK (0.36) | SYKFAAHCES1MTORACP1 | |
| SCHEMBL23993207 | 0.91 | MDM2 (0.37) | PDE10A | |
| SCHEMBL30224137 | 0.91 | MDM2 (0.37) | PDE10A | |
| SCHEMBL23993117 | 0.87 | PDE10A (0.35) | SYKMTORPDE10APPARD | |
| SCHEMBL29467425 | 0.87 | MTOR (0.36) | SYKMTORACP1PDE10APPARD | |
| SCHEMBL23993918 | 0.85 | SYK (0.38) | SYKFAAHCES1MTORACP1 | |
| SCHEMBL25005777 | 0.83 | SYK (0.41) | SYKFAAHCES1MTORACP1 | |
| SCHEMBL23994827 | 0.83 | SYK (0.41) | SYKFAAHCES1MTORACP1 | |
| SCHEMBL23993986 | 0.83 | SYK (0.37) | SYKMTORACP1PDE10APPARD | |
| SCHEMBL23994182 | 0.83 | SYK (0.37) | SYKMTORACP1PDE10APPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |