Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 10/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23993708 | 0.91 | NT5E (0.40) | NT5E | |
| SCHEMBL23993084 | 0.87 | NT5E (0.39) | NT5ECCNE1CDK2ALDH1A1LMNA | |
| SCHEMBL23994771 | 0.87 | NT5E (0.38) | NT5ECCNE1CDK2ALDH1A1 | |
| SCHEMBL24514953 | 0.83 | NT5E (0.62) | NT5E | |
| SCHEMBL23993660 | 0.82 | NT5E (0.43) | NT5EATAD2ALDH1A1JAK2JAK1 | |
| SCHEMBL23992789 | 0.78 | NT5E (0.42) | NT5ECCNE1CDK2ALDH1A1 | |
| SCHEMBL23994392 | 0.78 | NT5E (0.38) | NT5ECCNE1CDK2ALDH1A1 | |
| SCHEMBL23994620 | 0.77 | NT5E (0.39) | NT5EALDH1A1 | |
| SCHEMBL23993731 | 0.76 | NT5E (0.39) | NT5ECCNE1CDK2ALDH1A1 | |
| SCHEMBL29614190 | 0.74 | NT5E (0.40) | NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022121914-A1 | OXO-NITROGEN RING DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2022-06-16 | — | — | WO | disclosed |
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |