Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994571 | 0.85 | KCNJ6 (0.39) | CYP17A1CYP1A2PDE2A | |
| SCHEMBL25004868 | 0.81 | PDE10A (0.33) | CYP17A1CYP1A2MAPK1PDE2A | |
| SCHEMBL23995229 | 0.79 | PDE10A (0.32) | — | |
| SCHEMBL25589575 | 0.79 | KCNJ6 (0.34) | CYP17A1CYP1A2MAPK1PDE2A | |
| SCHEMBL23994564 | 0.77 | HTR2A (0.39) | MAPK1 | |
| SCHEMBL25270071 | 0.77 | FFAR1 (0.35) | MAPK1 | |
| SCHEMBL25004509 | 0.77 | HTR2A (0.40) | MAPK1 | |
| SCHEMBL23993628 | 0.77 | NT5E (0.34) | MAPK1 | |
| SCHEMBL23994572 | 0.77 | NT5E (0.34) | MAPK1 | |
| SCHEMBL25590352 | 0.77 | FFAR1 (0.35) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230039553-A1 | CD73 COMPOUNDS | ENTPD5, ENTPD1, NT5E | CYP17A1 4392/4885CYP1A2 3166/4885MAPK1 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.