Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 20/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 20/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 20/20 | 0.68 |
| ▸ | PRKDC | P78527 | 20/20 | 0.68 |
| ▸ | ABL1 | P00519 | 19/20 | 0.68 |
| ▸ | EGFR | P00533 | 19/20 | 0.68 |
| ▸ | HCK | P08631 | 19/20 | 0.68 |
| ▸ | SRC | P12931 | 19/20 | 0.68 |
| ▸ | KDR | P35968 | 19/20 | 0.68 |
| ▸ | MTOR | P42345 | 19/20 | 0.68 |
| ▸ | EPHB4 | P54760 | 19/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 10/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23997147 | 0.94 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30320600 | 0.94 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL24096501 | 0.90 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL30320491 | 0.90 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL24096758 | 0.90 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL29998830 | 0.90 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL5804408 | 0.88 | SRC (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL5804409 | 0.88 | SRC (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL5803264 | 0.88 | SRC (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL5801690 | 0.88 | SRC (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226547-A2 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. (US) | 2021-11-11 | — | — | WO | disclosed |