SCHEMBL24006111

SCHEMBL24006111

Cc1ccc2nccc(Nc3cccc(NC(=O)c4ccc(Nc5ccncc5)cc4)c3)c2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 8/20 0.66
DNMT3A Q9Y6K1 7/20 0.66
USP2 O75604 2/20 0.62
MAPT P10636 2/20 0.62
KMT2A Q03164 2/20 0.62
DNMT3L Q9UJW3 5/20 0.58
KCNK3 O14649 1/20 0.53
KCNK9 Q9NPC2 1/20 0.53
KDM4E B2RXH2 2/20 0.51
ALDH1A1 P00352 2/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
HPGD P15428 1/20 0.51
NFKB1 P19838 1/20 0.51
CYP2C19 P33261 1/20 0.51
KLK7 P49862 1/20 0.51
NFKB2 Q00653 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24003982 1.00 DNMT1 (0.66) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL30290952 0.94 DNMT1 (0.62) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL24006421 0.94 DNMT1 (0.62) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL24010295 0.94 DNMT1 (0.62) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL30180382 0.93 DNMT1 (0.72) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL23999647 0.93 DNMT1 (0.72) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL23261798 0.93 DNMT1 (0.72) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL24003959 0.92 DNMT1 (0.69) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL24006224 0.92 DNMT1 (0.69) DNMT1DNMT3AUSP2MAPTKMT2A
SCHEMBL26314528 0.91 USP2 (0.55) DNMT1DNMT3AUSP2MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023081854-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
WO-2021226477-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2021-11-11 WO disclosed