SCHEMBL24006169

SCHEMBL24006169

N#Cc1ccc2nccc(Nc3cccc(C(=O)Nc4ccc(Nc5ccccc5)cc4)c3)c2c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 9/20 0.70
DNMT3A Q9Y6K1 8/20 0.70
DNMT3L Q9UJW3 5/20 0.55
EHMT1 Q9H9B1 3/20 0.55
KMT2A Q03164 2/20 0.49
USP2 O75604 1/20 0.49
MAPT P10636 1/20 0.49
BRAF P15056 1/20 0.49
MAPKAPK2 P49137 2/20 0.48
GAK O14976 1/20 0.48
RIPK2 O43353 1/20 0.48
COQ8A Q8NI60 1/20 0.48
NLK Q9UBE8 1/20 0.48
CCNC P24863 1/20 0.47
CDK8 P49336 1/20 0.47
F2 P00734 1/20 0.47
PLG P00747 1/20 0.47
PLAU P00749 1/20 0.47
KLKB1 P03952 1/20 0.47
PRSS1 P07477 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24010972 0.96 DNMT1 (0.64) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL25820730 0.96 DNMT1 (0.64) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL31395379 0.94 DNMT1 (0.65) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL30287672 0.94 DNMT1 (0.65) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL24003769 0.94 DNMT1 (0.65) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL23244629 0.94 DNMT1 (0.65) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL30180621 0.93 DNMT1 (0.65) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL23999573 0.93 DNMT1 (0.65) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL30290777 0.92 DNMT1 (0.59) DNMT1DNMT3ADNMT3LEHMT1KMT2A
SCHEMBL25821812 0.92 DNMT1 (0.59) DNMT1DNMT3ADNMT3LEHMT1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023081854-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
WO-2023081845-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
WO-2021226477-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2021-11-11 WO disclosed