SCHEMBL24006358

SCHEMBL24006358

NS(=O)(=O)c1ccc2nccc(Nc3cccc(C(=O)Nc4ccc(Nc5ccncc5)cc4)c3)c2c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 8/20 0.64
DNMT3A Q9Y6K1 7/20 0.64
KMT2A Q03164 3/20 0.58
USP2 O75604 2/20 0.58
MAPT P10636 2/20 0.58
CA9 Q16790 2/20 0.55
DNMT3L Q9UJW3 5/20 0.53
EHMT1 Q9H9B1 3/20 0.53
POLB P06746 2/20 0.52
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 1/20 0.52
THRB P10828 1/20 0.52
MAPK1 P28482 1/20 0.52
MCL1 Q07820 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
CASP6 P55212 1/20 0.46
CTDSP1 Q9GZU7 1/20 0.46
MEN1 O00255 1/20 0.45
RIPK2 O43353 1/20 0.43
MYC P01106 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24009936 0.96 DNMT1 (0.58) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL24004051 0.93 DNMT1 (0.61) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL23999362 0.91 MAPT (0.69) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL24006360 0.91 DNMT1 (0.64) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL25820587 0.91 DNMT1 (0.63) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL30290892 0.87 DNMT1 (0.58) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL24009937 0.87 DNMT1 (0.58) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL24006109 0.85 DNMT1 (0.69) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL24006224 0.85 DNMT1 (0.69) DNMT1DNMT3AKMT2AUSP2MAPT
SCHEMBL24003959 0.85 DNMT1 (0.69) DNMT1DNMT3AKMT2AUSP2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023081854-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
WO-2023081845-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
WO-2021226477-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2021-11-11 WO disclosed