Sugi Predict

Sugi Predict / Compounds / SCHEMBL24007052

SCHEMBL24007052

SCHEMBL24007052

CC(=O)Nc1cc(Oc2ccc3nc(Nc4ccc(Cl)c(C(F)(F)F)c4)n(C)c3c2)ccn1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 17/20 0.68
▸ RAF1 P04049 2/20 0.65
▸ KDR P35968 6/20 0.57
▸ LCK P06239 1/20 0.57
▸ FYN P06241 1/20 0.57
▸ PDGFRB P09619 1/20 0.57
▸ KIT P10721 1/20 0.57
▸ SRC P12931 1/20 0.57
▸ FLT1 P17948 1/20 0.57
▸ FLT4 P35916 1/20 0.57
▸ HDAC3 O15379 2/20 0.51
▸ HDAC4 P56524 2/20 0.51
▸ HDAC1 Q13547 2/20 0.51
▸ HDAC7 Q8WUI4 2/20 0.51
▸ HDAC2 Q92769 2/20 0.51
▸ HDAC10 Q969S8 2/20 0.51
▸ HDAC11 Q96DB2 2/20 0.51
▸ HDAC8 Q9BY41 2/20 0.51
▸ HDAC6 Q9UBN7 2/20 0.51
▸ HDAC9 Q9UKV0 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4325129 0.93 BRAF (0.78) BRAFRAF1KDRLCKFYN
SCHEMBL30313590 0.87 BRAF (0.57) BRAFRAF1KDRLCKFYN
SCHEMBL24007226 0.87 BRAF (0.57) BRAFRAF1KDRLCKFYN
SCHEMBL4339509 0.85 BRAF (0.78) BRAFRAF1KDRLCKFYN
SCHEMBL24374954 0.84 BRAF (0.60) BRAFRAF1KDRLCKFYN
SCHEMBL4322244 0.84 BRAF (0.79) BRAFRAF1KDRLCKFYN
SCHEMBL24007134 0.83 ABL1 (0.60) BRAFKDRLCKFYNPDGFRB
SCHEMBL19564935 0.83 BRAF (0.86) BRAFRAF1KDRLCKFYN
SCHEMBL24007018 0.83 BRAF (0.58) BRAFRAF1KDRLCKFYN
SCHEMBL24007574 0.82 BRAF (0.58) BRAFRAF1KDRLCKFYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230265075-A1 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS AJAX THERAPEUTICS, INC. 2023-08-24 — — US disclosed
US-11691963-B2 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors AJAX THERAPEUTICS, INC. (US) 2023-07-04 — — US disclosed
CN-115996917-A 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors 艾捷斯治疗公司 2023-04-21 — — CN disclosed
US-20220411403-A1 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS AJAX THERAPEUTICS, INC. 2022-12-29 — — US disclosed
WO-2021226261-A1 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS AJAX THERAPEUTICS, INC. (US) 2021-11-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220411403-A1 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS JAK2, JAK3, STAT5B BRAF 733/4885RAF1 2140/4885KDR 349/4885
US-20230265075-A1 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS JAK2, JAK3, STAT5B BRAF 733/4885RAF1 2140/4885KDR 349/4885
US-11691963-B2 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors JAK2, JAK3, STAT5B BRAF 733/4885RAF1 2140/4885KDR 349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.