Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24813943 | 0.85 | CHRM2 (0.36) | CHRM2CHRM4CHRM5CHRM3CNR1 | |
| SCHEMBL24815009 | 0.85 | MAP3K14 (0.36) | CHRM2CHRM4CHRM5CHRM3CNR1 | |
| SCHEMBL24007224 | 0.84 | CHRM2 (0.33) | CHRM2CHRM4CHRM5CHRM3CNR1 | |
| SCHEMBL26013186 | 0.80 | CNR2 (0.39) | CNR1CNR2 | |
| SCHEMBL24815013 | 0.80 | SLC6A2 (0.37) | CNR1CNR2MAP3K14 | |
| SCHEMBL24008003 | 0.79 | PTGER4 (0.30) | PTGER4MAP3K14 | |
| SCHEMBL18948371 | 0.71 | CHRM2 (0.35) | CHRM2CHRM4CHRM5CHRM3PTGER4 | |
| SCHEMBL26012444 | 0.71 | CNR1 (0.42) | CNR1CNR2 | |
| SCHEMBL26013187 | 0.70 | CNR2 (0.35) | CNR2 | |
| SCHEMBL13192102 | 0.69 | CNR1 (0.35) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226261-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |