Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.61 |
| ▸ | MET | P08581 | 3/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23999470 | 0.91 | KDR (0.73) | KDRMET | |
| SCHEMBL24006212 | 0.91 | KDR (0.73) | KDRMET | |
| SCHEMBL24003904 | 0.90 | KDR (0.71) | KDRMETCYP11B1 | |
| SCHEMBL24006228 | 0.90 | KDR (0.71) | KDRMETCYP11B1 | |
| SCHEMBL24009927 | 0.87 | KDR (0.52) | KDRCYP11B1GAKCCNCCDK8 | |
| SCHEMBL24006229 | 0.86 | KDR (0.52) | KDRGAK | |
| SCHEMBL23999511 | 0.85 | KDR (0.63) | KDRMETGAKCCNCCDK8 | |
| SCHEMBL30180360 | 0.85 | KDR (0.63) | KDRMETGAKCCNCCDK8 | |
| SCHEMBL23999699 | 0.85 | KDR (0.63) | KDRMETGAKCCNCCDK8 | |
| SCHEMBL30210280 | 0.85 | KDR (0.63) | KDRMETGAKCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| US-20230219927-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-07-13 | — | — | US | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021226458-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219927-A1 | AKT3 MODULATORS | AKT3, AKT2, PIK3CA | KDR 2851/4885MET 1110/4885CYP11B1 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.