SCHEMBL24010779

SCHEMBL24010779

O=Cc1nc(Cn2nc(-c3ccc(Cl)cc3)n(CCC(F)(F)F)c2=O)nn1-c1ccccc1C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 20/20 0.50
AVPR1A P37288 20/20 0.50
SLC6A2 P23975 1/20 0.42
OXTR P30559 1/20 0.42
OPRK1 P41145 1/20 0.42
AVPR1B P47901 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24010541 0.90 AVPR2 (0.48) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19568127 0.87 AVPR2 (0.52) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19577179 0.85 AVPR2 (0.52) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19568180 0.85 AVPR2 (0.50) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19570363 0.85 AVPR2 (0.55) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19577238 0.84 AVPR2 (0.47) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19577230 0.84 AVPR2 (0.49) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL24010772 0.83 AVPR2 (0.53) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19577163 0.81 AVPR2 (0.48) AVPR2AVPR1ASLC6A2OXTROPRK1
SCHEMBL19568220 0.81 AVPR2 (0.59) AVPR2AVPR1ASLC6A2OXTROPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3700913-B1 PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF BAYER AG (DE) 2021-11-10 EP disclosed