Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.82 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.60 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205988 | 0.90 | NOTUM (1.00) | NOTUMTP53CYP11B2CYP11B1LMNA | |
| SCHEMBL24011066 | 0.88 | NOTUM (0.63) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL26763821 | 0.84 | NOTUM (0.58) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL156256 | 0.83 | NOTUM (0.82) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL6721657 | 0.83 | NOTUM (0.64) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL11709696 | 0.82 | HDAC1 (0.57) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL7416330 | 0.81 | NOTUM (0.62) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL20894496 | 0.81 | NOTUM (0.62) | NOTUMPDK1PDK2PDK3PDK4 | |
| SCHEMBL3102790 | 0.81 | NOTUM (0.62) | NOTUMTP53CYP11B2CYP11B1LMNA | |
| SCHEMBL19657371 | 0.81 | NOTUM (0.62) | NOTUMTP53CYP11B2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196512-A1 | PROPARGYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT MODULATE BRD4 | Plexium, Inc. (US) | 2023-10-12 | — | — | WO | disclosed |
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |