Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MGLL | Q99685 | 9/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011203 | 0.92 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MGLLMCHR1 | |
| SCHEMBL24011194 | 0.90 | MCHR1 (0.60) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011230 | 0.90 | EPHX2 (0.61) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011089 | 0.89 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011198 | 0.89 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011324 | 0.88 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011091 | 0.88 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011326 | 0.88 | GAA (0.57) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011481 | 0.88 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011202 | 0.87 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-11-02 | — | — | US | disclosed |
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | NAMPT, NNT, NAPRT | NPC1 128/4885RAB9A 814/4885SMN1; SMN2 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.