Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24012214 | 0.97 | HDAC6 (0.63) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL19138892 | 0.90 | HDAC6 (0.71) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL24012069 | 0.89 | HDAC6 (0.79) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL20634145 | 0.88 | HDAC6 (0.80) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL17520651 | 0.87 | HDAC6 (0.64) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL24011766 | 0.85 | HDAC6 (0.61) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL17520655 | 0.85 | HDAC6 (0.83) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL24012096 | 0.84 | HDAC6 (0.62) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL24011879 | 0.84 | HDAC6 (0.77) | HDAC6HDAC2HDAC8HDAC3HDAC1 | |
| SCHEMBL17520600 | 0.83 | HDAC6 (0.64) | HDAC6HDAC2HDAC8HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177621-B1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIV REGENSBURG (DE) | 2021-11-10 | — | — | EP | disclosed |