Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.66 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.66 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.66 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.38 |
| ▸ | KCNQ4 | P56696 | 2/20 | 0.38 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30055916 | 0.91 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24015646 | 0.91 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24016573 | 0.89 | TEAD1 (0.69) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24015665 | 0.85 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24016542 | 0.85 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24015783 | 0.85 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24016138 | 0.85 | TEAD1 (0.63) | TEAD1TEAD4TEAD2TEAD3LMNA | |
| SCHEMBL24015631 | 0.84 | TEAD1 (0.68) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24015890 | 0.83 | TEAD1 (0.66) | TEAD1TEAD4TEAD2TEAD3ADORA3 | |
| SCHEMBL24016571 | 0.82 | TEAD1 (0.64) | TEAD1TEAD4TEAD2TEAD3ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |