Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.46 |
| ▸ | UBE2M | P61081 | 1/20 | 0.45 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25132815 | 1.00 | HCRTR1 (0.46) | HCRTR1HCRTR2UBE2MDCUN1D1TSHR | |
| SCHEMBL18532595 | 1.00 | HCRTR1 (0.46) | HCRTR1HCRTR2UBE2MDCUN1D1TSHR | |
| SCHEMBL14959024 | 1.00 | HCRTR1 (0.46) | HCRTR1HCRTR2UBE2MDCUN1D1TSHR | |
| SCHEMBL12176376 | 0.92 | NPSR1 (0.44) | HCRTR1HCRTR2UBE2MDCUN1D1TSHR | |
| SCHEMBL20879813 | 0.92 | CYP2C9 (0.46) | HCRTR1HCRTR2UBE2MDCUN1D1TSHR | |
| SCHEMBL14959027 | 0.92 | CYP2C9 (0.46) | HCRTR1HCRTR2UBE2MDCUN1D1TSHR | |
| SCHEMBL17805395 | 0.91 | EPHX2 (0.41) | UBE2MDCUN1D1TSHRCYP2C9NPSR1 | |
| SCHEMBL14959034 | 0.91 | EPHX2 (0.41) | UBE2MDCUN1D1TSHRCYP2C9NPSR1 | |
| SCHEMBL18790108 | 0.91 | EPHX2 (0.41) | UBE2MDCUN1D1TSHRCYP2C9NPSR1 | |
| SCHEMBL18609353 | 0.91 | EPHX2 (0.41) | UBE2MDCUN1D1TSHRCYP2C9NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508477-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2021-11-10 | — | — | EP | disclosed |