SCHEMBL24017017

SCHEMBL24017017

Cc1cc(C)cc(C(O)(c2cc(C)cc(C)c2)[C@H](O)c2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 5/20 0.41
AOC3 Q16853 1/20 0.41
SLC6A2 P23975 5/20 0.37
SLC6A4 P31645 5/20 0.37
SLC6A3 Q01959 3/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2D6 P10635 2/20 0.37
KCNH2 Q12809 1/20 0.37
ADRA2C P18825 2/20 0.36
CHRM2 P08172 1/20 0.36
ADRA1A P35348 1/20 0.36
RGS12 O14924 1/20 0.36
GLA P06280 1/20 0.36
CYP2C9 P11712 1/20 0.36
PKM P14618 1/20 0.36
ALOX15 P16050 1/20 0.36
TSHR P16473 1/20 0.36
ALOX12 P18054 1/20 0.36
NFKB1 P19838 1/20 0.36
HTR2A P28223 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24017072 1.00 TACR1 (0.41) TACR1AOC3SLC6A2SLC6A4SLC6A3
SCHEMBL2172547 0.80 KCNA5 (0.46) AOC3CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL1868206 0.80 KCNA5 (0.46) AOC3CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL703021 0.80 KCNA5 (0.46) AOC3CYP3A4CYP2D6CYP2C9TSHR
SCHEMBL416186 0.79 CYP2D6 (0.41) AOC3CYP3A4CYP2D6TSHRALOX12
SCHEMBL29220604 0.75 KCNA5 (0.42) AOC3SLC6A2SLC6A4SLC6A3CYP3A4
SCHEMBL24017019 0.74 HTT (0.44) TACR1AOC3SLC6A2SLC6A4SLC6A3
SCHEMBL24017111 0.74 MEN1 (0.45) AOC3SLC6A2SLC6A4SLC6A3ALOX12
SCHEMBL24017121 0.74 HTT (0.44) TACR1AOC3SLC6A2SLC6A4SLC6A3
SCHEMBL24017018 0.74 MEN1 (0.45) AOC3SLC6A2SLC6A4SLC6A3ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021223156-A1 DIBORON GLYCOL ESTER, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF, AND APPLICATION THEREOF 中国科学院上海有机化学研究所 2021-11-11 WO disclosed