SCHEMBL24027360

SCHEMBL24027360

CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCCN(C)C3)c2n1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 20/20 0.78
FGFR2 P21802 7/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16997089 0.95 FGFR1 (0.78) FGFR1FGFR2
SCHEMBL24027460 0.95 FGFR1 (0.78) FGFR1FGFR2
SCHEMBL16993026 0.92 FGFR1 (0.75) FGFR1FGFR2
SCHEMBL16993430 0.88 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL17910106 0.87 FGFR1 (0.79) FGFR1FGFR2
SCHEMBL16992993 0.86 FGFR1 (0.73) FGFR1FGFR2
SCHEMBL20227914 0.85 FGFR1 (0.89) FGFR1FGFR2
SCHEMBL16992996 0.85 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16992994 0.85 FGFR1 (1.00) FGFR1FGFR2
SCHEMBL16992995 0.85 FGFR1 (1.00) FGFR1FGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298011-B1 QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2021-11-17 EP disclosed