Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25972872 | 0.93 | POLB (0.43) | POLBPIK3CDKMT2AHRH3ACHE | |
| SCHEMBL25972865 | 0.93 | POLB (0.43) | POLBPIK3CDKMT2AHRH3ACHE | |
| SCHEMBL21105875 | 0.91 | POLB (0.46) | POLBPIK3CDKMT2AHRH3TLR9 | |
| SCHEMBL21107438 | 0.91 | POLB (0.46) | POLBPIK3CDKMT2AHRH3TLR9 | |
| SCHEMBL22861852 | 0.91 | POLB (0.46) | POLBPIK3CDKMT2AHRH3TLR9 | |
| SCHEMBL25924838 | 0.89 | KMT2A (0.46) | POLBPIK3CDKMT2AHRH3TLR9 | |
| SCHEMBL23806986 | 0.87 | POLB (0.39) | POLBPIK3CDKMT2A | |
| SCHEMBL23696444 | 0.87 | POLB (0.39) | POLBPIK3CDKMT2A | |
| SCHEMBL26280669 | 0.85 | KMT2A (0.47) | KMT2AACHE | |
| SCHEMBL26280673 | 0.85 | KMT2A (0.47) | KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192578-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2021231778-A1 | CORONAVIRUS PROTEASE DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-11-18 | — | — | WO | disclosed |