Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 8/20 | 0.39 |
| ▸ | PLK1 | P53350 | 8/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24030221 | 0.88 | CRBN (0.55) | ARCRBNBTKDDB1IRAK1 | |
| SCHEMBL24030322 | 0.88 | AR (0.60) | ARCRBNBTKDDB1IKZF3 | |
| SCHEMBL24506843 | 0.84 | BTK (0.54) | ARCRBNBTKIRAK1IRAK4 | |
| SCHEMBL28909484 | 0.84 | AR (0.79) | ARCRBN | |
| SCHEMBL23260073 | 0.84 | AR (0.79) | ARCRBN | |
| SCHEMBL23129053 | 0.82 | CRBN (0.51) | ARCRBNBTKDDB1IKZF3 | |
| SCHEMBL22565512 | 0.82 | AR (0.52) | ARCRBNBTKDDB1IKZF3 | |
| SCHEMBL24507033 | 0.81 | AR (0.49) | ARCRBNBTKDDB1IKZF3 | |
| SCHEMBL22661504 | 0.81 | AR (0.54) | ARCRBNBTKDDB1IKZF3 | |
| SCHEMBL22661366 | 0.81 | AR (0.54) | ARCRBNBTKDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023205481-A1 | A COMBINATION FOR USE IN TREATING PROSTATE CANCER COMPRISING ARV-100 AND ABIRATERONE | ARVINAS OPERATIONS, INC. (US) | 2023-10-26 | — | — | WO | disclosed |
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |
| WO-2021231431-A1 | METHODS OF TREATING PROSTATE CANCER | ARVINAS OPERATIONS, INC. (US) | 2021-11-18 | — | — | WO | disclosed |