Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | BCL2L11 | O43521 | 10/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25813892 | 0.84 | MCL1 (0.42) | MCL1CCND1KDM1ASIGMAR1BCL2L11 | |
| SCHEMBL22894800 | 0.84 | MCL1 (0.42) | MCL1CCND1KDM1ASIGMAR1BCL2L11 | |
| SCHEMBL25670137 | 0.84 | MCL1 (0.42) | MCL1CCND1SIGMAR1BCL2L11 | |
| SCHEMBL24461727 | 0.84 | MCL1 (0.42) | MCL1CCND1KDM1ASIGMAR1BCL2L11 | |
| SCHEMBL29414585 | 0.84 | MCL1 (0.42) | MCL1CCND1KDM1ASIGMAR1BCL2L11 | |
| SCHEMBL30261895 | 0.82 | MCL1 (0.41) | MCL1CCND1KDM1ASIGMAR1BCL2L11 | |
| SCHEMBL21930487 | 0.82 | MCL1 (0.41) | MCL1CCND1KDM1ASIGMAR1BCL2L11 | |
| SCHEMBL22975900 | 0.82 | MCL1 (0.47) | MCL1CCND1SIGMAR1BCL2L11 | |
| SCHEMBL24461875 | 0.82 | MCL1 (0.40) | MCL1CCND1KDM1ASIGMAR1BCL2L11 | |
| SCHEMBL17542338 | 0.81 | MCL1 (0.58) | MCL1CCND1BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231737-A1 | SPIRO-SULFONAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2021-11-18 | — | — | WO | disclosed |