Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.48 |
| ▸ | KDR | P35968 | 10/20 | 0.43 |
| ▸ | FLT1 | P17948 | 9/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.43 |
| ▸ | FLT4 | P35916 | 5/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KIF5B | P33176 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 6/20 | 0.42 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24037412 | 0.86 | EGFR (0.57) | EGFR | |
| SCHEMBL21616332 | 0.86 | EGFR (0.48) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL24037410 | 0.86 | KDR (0.52) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL30203115 | 0.86 | EGFR (0.48) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL24037411 | 0.85 | EGFR (0.44) | EGFREPHA2ERBB4EPHB4 | |
| SCHEMBL21616281 | 0.83 | EGFR (0.49) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL23355315 | 0.82 | EGFR (0.48) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL21616265 | 0.81 | EGFR (0.47) | EGFRKDRFLT1FGFR1FLT4 | |
| SCHEMBL24037712 | 0.81 | EGFR (0.61) | EGFR | |
| SCHEMBL21612780 | 0.81 | EGFR (0.61) | EGFRRETEPHB2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231400-A1 | BIS-ARYL ETHERS CONTAINING N-ACYL AZETIDINE AS EGFR/HER2 INHIBITORS | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2021-11-18 | — | — | WO | disclosed |