Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ipragliflozin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 known ✓ | P31639 | 20/20 | 1.00 |
| ▸ | SLC5A1 | P13866 | 5/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ipragliflozin SCHEMBL27177473 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL18573706 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL17034641 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL903239 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL23731432 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL29433938 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL29358545 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL337645 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL11971945 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A | |
| Ipragliflozin SCHEMBL9908293 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1SLC6A3CHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021227441-A1 | ARYL GLUCOSIDE DERIVATIVE AND USE THEREOF IN DRUG | 上海喆邺生物科技有限公司 | 2021-11-18 | — | — | WO | disclosed |