SCHEMBL2404465

SCHEMBL2404465

O=C(O)c1cccc(-c2cc(Cl)cc([N+](=O)[O-])c2O)c1

nearest known ligand 0.57

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 3/20 0.57
RXRA P19793 1/20 0.52
RXRB P28702 1/20 0.52
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
TP53 P04637 1/20 0.47
CASP6 P55212 1/20 0.44
TTR P02766 1/20 0.44
DUSP3 P51452 1/20 0.43
KMO O15229 1/20 0.43
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29386074 1.00 ERN1 (0.57) ERN1RXRARXRBCRHBPCRHR2
SCHEMBL408308 0.86 ERN1 (0.59) ERN1RXRARXRBCRHBPCRHR2
SCHEMBL2404933 0.86 TTR (0.48) ERN1CRHBPCRHR2CASP6TTR
SCHEMBL31415060 0.86 ERN1 (0.59) ERN1RXRARXRBCRHBPCRHR2
SCHEMBL4348393 0.85 ERN1 (0.54) ERN1RXRARXRBCRHBPCRHR2
SCHEMBL3360547 0.84 ERN1 (0.57) ERN1CRHBPCRHR2TP53CASP6
SCHEMBL3360693 0.84 ERN1 (0.57) ERN1CRHBPCRHR2TP53CASP6
Bromide SCHEMBL3516464 0.83 ERN1 (0.56) ERN1CRHBPCRHR2TP53CASP6
SCHEMBL14086411 0.83 TPMT (0.49) ERN1RXRARXRBTP53CASP6
SCHEMBL2407536 0.82 HCAR2 (0.46) ERN1CRHBPCRHR2CASP6TTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040019190-A1 Thrombopoietin mimetics NOVARTIS AG (CH) 2004-01-29 US claimed
US-12435042-B2 Process for the preparation of key intermediates for the synthesis of Eltrombopag or salt thereof F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) 2025-10-07 US disclosed
US-20220298116-A1 PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF ELTROMBOPAG OR SALT THEREOF F.l.S. - FABBRICA ITALIANA SINTETICI S.P.A (IT) 2022-09-22 US disclosed
EP-3994126-A1 PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF ELTROMBOPAG OR SALT THEREOF F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) 2022-05-11 EP disclosed
WO-2021001044-A1 PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF ELTROMBOPAG OR SALT THEREOF F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) 2021-01-07 WO disclosed
US-20150093356-A1 THROMBOPOIETIN MIMETICS GLAXOSMITHKLINE LLC 2015-04-02 US disclosed
WO-2013049605-A1 PROCESSES FOR THE PREPARATION OF AN INTERMEDIATE IN THE SYNTHESIS OF ELTROMBOPAG ASSIA CHEMICAL INDUSTRIES LTD. (IL) 2013-04-04 WO disclosed
WO-2013049605-A1 PROCESSES FOR THE PREPARATION OF AN INTERMEDIATE IN THE SYNTHESIS OF ELTROMBOPAG ASSIA CHEMICAL INDUSTRIES LTD. (IL) 2013-04-04 WO disclosed
US-20130078213-A1 THROMBOPOIETIN MIMETICS GLAXOSMITHKLINE LLC 2013-03-28 US disclosed
US-20110212054-A1 THROMBOPOIETIN MIMETICS GLAXOSMITHKLINE LLC. 2011-09-01 US disclosed
EP-1889838-A1 Thrombopoietin mimetics SmithKline Beecham Corporation (US) 2008-02-20 EP disclosed
US-7332481-B2 Thrombopoietin mimetics SMITHKLINE BEECHAM CORPORATION (US) 2008-02-19 US disclosed
EP-1864981-A1 Thrombopoietin mimetics SmithKline Beecham Corporation (US) 2007-12-12 EP disclosed
US-20070179192-A1 THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORPORATION AND GLAXO GROUP LIMITED 2007-08-02 US disclosed
US-20070129338-A1 THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORPORATION 2007-06-07 US disclosed
US-7160870-B2 Thrombopoietin mimetics SMITHKLINE BEECHAM CORPORATION (US) 2007-01-09 US disclosed
US-20040019190-A1 Thrombopoietin mimetics NOVARTIS AG (CH) 2004-01-29 US disclosed
EP-1294378-A4 THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORP (US) 2004-01-28 EP disclosed
EP-1294378-A2 THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORPORATION (US) 2003-03-26 EP disclosed
WO-2001089457-A2 THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORPORATION (US) 2001-11-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070129338-A1 THROMBOPOIETIN MIMETICS MPL, THPO, TEK ERN1 4239/4885RXRA 4434/4885RXRB 2974/4885
US-20070179192-A1 THROMBOPOIETIN MIMETICS MPL, THPO, TEK ERN1 4239/4885RXRA 4434/4885RXRB 2974/4885
US-20150093356-A1 THROMBOPOIETIN MIMETICS MPL, THPO, TEK ERN1 4239/4885RXRA 4434/4885RXRB 2974/4885
US-12435042-B2 Process for the preparation of key intermediates for the synthesis of Eltrombopag or salt thereof HABP2, F5, THPO ERN1 2591/4885RXRA 3185/4885RXRB 3068/4885
US-20110212054-A1 THROMBOPOIETIN MIMETICS MPL, THPO, TEK ERN1 4239/4885RXRA 4434/4885RXRB 2974/4885
US-20130078213-A1 THROMBOPOIETIN MIMETICS MPL, THPO, TEK ERN1 4239/4885RXRA 4434/4885RXRB 2974/4885
US-20220298116-A1 PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF ELTROMBOPAG OR SALT THEREOF HABP2, F5, THPO ERN1 2591/4885RXRA 3185/4885RXRB 3068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.